ProfileDB Home Log in
PoPS Results
Results for search of PMAP proteome protein hs.25211 by PoPS model 'MMP16_logodds.prts'
- Disordered substrate prediction was not applied
- Sites predicted to be in N- terminal regions (<=30aa) were removed
- PFAM protein filter was not applied
- Secondary structure prediction was not applied
- Screening by protein localization was not applied
Predicted localization (site and confidence): plasma membrane (0.82), ER (0.09), nuclear (0.06)
| Position | Cleavage sequence | PoPS score |
|---|
| N579-M580 | LANMIS | 6.129 |
| M493-L494 | FNMLKK | 4.567 |
| N492-M493 | VFNMLK | 4.465 |
| H533-L534 | MTHLRV | 4.301 |
| Q525-I526 | AAQIRS | 3.949 |
| M722-L723 | LVMLKK | 3.424 |
| Q767-M768 | FEQMQN | 3.348 |
| S441-L442 | VESLEQ | 3.233 |
| A463-M464 | VEAMLN | 3.077 |
| H514-V515 | FEHVRM | 3.004 |
| PFAM domain | Domain Name | Start | End | E-value |
|---|
| PF02177 | Amyloid A4 extracellular domain | 24 | 188 | 1.2e-215 |
| PF00014 | Kunitz/Bovine pancreatic trypsin inhi | 290 | 342 | 2.2e-34 |
| PF03494 | Beta-amyloid peptide (beta-APP) | 675 | 713 | 3.9e-27 |
1 11 21 31 41 51 61 71
+---------+---------+---------+---------+---------+---------+---------+---------
SUBSTRATE: MLPGLALLLLAAWTARALEVPTDGNAGLLAEPQIAMFCGRLNMHMNVQNGKWDSDPSGTKTCIDTKEGILQYCQEVYPEL
SITES:
DISORDER: ~~~~~~~~~
SECONDARY: ---HHHHHHHHHHHHHHHH---------HHHHHHHHHHHH----EE-------------EEEEE----HHHHHHHH----
DOMAINS: @@@@@@@@@@@@@@@@@@@@@@@@@@@@@@@@@@@@@@@@@@@@@@@@@@@@@@@@@
81 91 101 111 121 131 141 151
+---------+---------+---------+---------+---------+---------+---------+---------
SUBSTRATE: QITNVVEANQPVTIQNWCKRGRKQCKTHPHFVIPYRCLVGEFVSDALLVPDKCKFLHQERMDVCETHLHWHTVAKETCSE
SITES:
DISORDER:
SECONDARY: EEEEEEE----EEEE----------------EEEEEE----HHHH---------HHHH---HHHHH----EEEEEE----
DOMAINS: @@@@@@@@@@@@@@@@@@@@@@@@@@@@@@@@@@@@@@@@@@@@@@@@@@@@@@@@@@@@@@@@@@@@@@@@@@@@@@@@
161 171 181 191 201 211 221 231
+---------+---------+---------+---------+---------+---------+---------+---------
SUBSTRATE: KSTNLHDYGMLLPCGIDKFRGVEFVCCPLAEESDNVDSADAEEDDSDVWWGGADTDYADGSEDKVVEVAEEEEVAEVEEE
SITES:
DISORDER: ~~~~~~~~~~~~~~~~~~~~ ~~~~~~~~~~~
SECONDARY: ---------------------EEEEE----------------------EE-------------HHHHHHHHHHHHHHHHH
DOMAINS: @@@@@@@@@@@@@@@@@@@@@@@@@@@@
241 251 261 271 281 291 301 311
+---------+---------+---------+---------+---------+---------+---------+---------
SUBSTRATE: EADDDEDDEDGDEVEEEAEEPYEEATERTTSIATTTTTTTESVEEVVREVCSEQAETGPCRAMISRWYFDVTEGKCAPFF
SITES:
DISORDER: ~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~ ~~~~~~
SECONDARY: ------------HHHHH------------EEEEEEEEEEEEEHHHHHHHH----------HHHHEEEEEE--------EE
DOMAINS: @@@@@@@@@@@@@@@@@@@@@@@@@@@@@@@
321 331 341 351 361 371 381 391
+---------+---------+---------+---------+---------+---------+---------+---------
SUBSTRATE: YGGCGGNRNNFDTEEYCMAVCGSAMSQSLLKTTQEPLARDPVKLPTTAASTPDAVDKYLETPGDENEHAHFQKAKERLEA
SITES:
DISORDER: ~ ~~~~~~~~~~~
SECONDARY: E------------HHHHHHH-----HHHHHH--------------------------EE-------HHHHHHHHHHHHHH
DOMAINS: @@@@@@@@@@@@@@@@@@@@@@
401 411 421 431 441 451 461 471
+---------+---------+---------+---------+---------+---------+---------+---------
SUBSTRATE: KHRERMSQVMREWEEAERQAKNLPKADKKAVIQHFQEKVESLEQEAANERQQLVETHMARVEAMLNDRRRLALENYITAL
SITES: * *
DISORDER: ~~~~~~~~~
SECONDARY: HHHHHHHHHHHHHHHHHHHHH------HHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHH
DOMAINS:
481 491 501 511 521 531 541 551
+---------+---------+---------+---------+---------+---------+---------+---------
SUBSTRATE: QAVPPRPRHVFNMLKKYVRAEQKDRQHTLKHFEHVRMVDPKKAAQIRSQVMTHLRVIYERMNQSLSLLYNVPAVAEEIQD
SITES: ** * * *
DISORDER:
SECONDARY: H--------HHHHHHHHHHHHH--HHHHHHHHHEEEE----HHHHHHHHHHHHHHHHHHH-----HHHH--HHHHHHHHH
DOMAINS:
561 571 581 591 601 611 621 631
+---------+---------+---------+---------+---------+---------+---------+---------
SUBSTRATE: EVDELLQKEQNYSDDVLANMISEPRISYGNDALMPSLTETKTTVELLPVNGEFSLDDLQPWHSFGADSVPANTENEVEPV
SITES: *
DISORDER: ~~~~~~~~~~~~~
SECONDARY: HHHHHHHHH-----EEEEEE---------------------EEEEE----------------------------------
DOMAINS:
641 651 661 671 681 691 701 711
+---------+---------+---------+---------+---------+---------+---------+---------
SUBSTRATE: DARPAADRGLTTRPGSGLTNIKTEEISEVKMDAEFRHDSGYEVHHQKLVFFAEDVGSNKGAIIGLMVGGVVIATVIVITL
SITES:
DISORDER: ~~~~ ~~~~~~~~~~~~~
SECONDARY: ------------------E--HHHHHHHHHHHHHHH-----HHHHHEEEEEEE------EEEEEEEE--EEEEEEEHHHH
DOMAINS: @@@@@@@@@@@@@@@@@@@@@@@@@@@@@@@@@@@@@@@
721 731 741 751 761
+---------+---------+---------+---------+---------
SUBSTRATE: VMLKKKQYTSIHHGVVEVDAAVTPEERHLSKMQQNGYENPTYKFFEQMQN
SITES: * *
DISORDER: ~~~~~~~~
SECONDARY: HHHH----EEE---EEEEE-----HHHHHHHHH----------EEE----
DOMAINS:
Top ProfileDB Home